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UID:20251104T044957EST-3907BEX5KX@132.216.98.100
DTSTAMP:20251104T094957Z
DESCRIPTION: \n\nDr. Bruce Stanton\n\nProfessor of Physiology\, Department 
 of Microbiology and Immunology\, Director of Cystic Fibrosis Research Deve
 lopment Program\, Director of Lung Biology Center\, Dartmouth Geisel Schoo
 l of Medicine\n\n \n\nTalk title: ‘’Host-Pathogen Interactions in Cystic F
 ibrosis: Role of Extracellular Vesicles and siRNA’’\n\n \n\nIn the healthy
  lung the opportunistic pathogen\, Pseudomonas aeruginosa\, is rapidly eli
 minated by mucociliary clearance\, a process that is dependent on the acti
 vity of the CFTR anion channel that\, in concert with a number of other tr
 ansport proteins\, regulates the volume and composition of the periciliary
  surface liquid. This fluid layer is essential to enable cilia to clear pa
 thogens from the lungs. However\, in cystic fibrosis (CF)\, mutations in t
 he CFTR gene reduce Cl and HCO3 secretion\, thereby decreasing periciliary
  surface liquid volume and mucociliary clearance of bacteria. In CF this l
 eads to persistent infection by P. aeruginosa\, which is the cause of redu
 ced lung function and death in ~95% of CF patients. Studies in our laborat
 ory have shown that P. aeruginosa inhibits both wt CFTR Cl secretion and d
 rug rescued Phe508del CFTR Cl secretion and the inflammatory response to i
 nfection by secreting outer membrane vesicles that contain virulence facto
 rs and siRNA. By contrast\, airway epithelial cells secrete extracellular 
 vesicles (EV) containing miRNA that increase the sensitivity of P. aerugin
 osa to antibiotics\, thereby reducing the infection. This bi-directionsl c
 ommunication between the host and pathogen is mediated by extracellular ve
 sicles.\n\n \n\nThis seminar will be given online via Zoom. Details in att
 ached poster.\n
DTSTART:20210423T150000Z
DTEND:20210423T160000Z
SUMMARY:CFTRc seminar - Dr. Bruce Stanton
URL:/cftrc/channels/event/cftrc-seminar-dr-bruce-stant
 on-330590
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