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DTSTAMP:20251028T155521Z
DESCRIPTION:Dr. Claire O'Callaghan presents\, 'The locus coeruleus-noradren
 aline system in Parkinson's disease\,'.\n\nRegistration via Eventbrite.\n
 \nLivestreaming via Vimeo. \n\nSpeaker: Claire O'Callaghan\, Ph.D.\n\nRese
 arch Fellow\, Faculty of Medicine\, University of Sydney\, Australia\n\nAb
 stract: The locus coeruleus–noradrenaline system plays an extensive role i
 n cognition and behaviour. Understanding how this system is impacted by di
 sease has important implications for treatment\, and can offer insights in
 to how the system functions in the healthy brain. My talk will focus on th
 e locus coeruleus–noradrenaline system in Parkinson’s disease – in particu
 lar\, the role it plays in impulsivity and reinforcement learning. Using a
  combined approach\, we characterised the locus coeruleus using 7T MRI and
  probed the system in a pharmacological study with the noradrenergic reupt
 ake inhibitor atomoxetine. Following on from extensive preclinical work li
 nking stop-signal inhibition to the noradrenergic system\, we show that st
 op-signal task performance is modulated by atomoxetine and dependent on lo
 cus coeruleus integrity. We also use this framework to further confirm a r
 ole for noradrenaline in navigating uncertainty during reinforcement learn
 ing\, by showing improved learning behaviour under atomoxetine via computa
 tional modelling and pupillometry. Together\, these findings advance ideas
  around noradrenergic therapy in Parkinson’s disease and hopefully provide
  some new insights into how the locus coeruleus–noradrenaline system orche
 strates human behaviour.\n\nBio: Claire is a research fellow at the Univer
 sity of Sydney. She works across cognitive and clinical neuroscience\, try
 ing to understand cognitive functions in the healthy brain and how they ar
 e affected in neurodegenerative conditions.\n\nShe trained as a clinical n
 europsychologist then completed her PhD in Sydney in 2015\, followed by a 
 postdoc at the University of Cambridge (2015-2019)\, before returning to S
 ydney in 2019.\n\nThe Feindel Virtual Brain and Mind (VBM) Seminar Series 
 will advance the vision of Dr. William Feindel (1918–2014)\, Former Direct
 or of the Neuro (1972–1984)\, to constantly bridge the clinical and resear
 ch realms. The talks will highlight the latest advances and discoveries in
  neuropsychology\, cognitive neuroscience\, and neuroimaging.\n\nSpeakers 
 will include scientists from across The Neuro\, as well as colleagues and 
 collaborators locally and from around the world. The series is intended to
  provide a virtual forum for scientists and trainees to continue to foster
  interdisciplinary exchanges on the mechanisms\, diagnosis and treatment o
 f brain and cognitive disorders.\n\n \n
DTSTART:20210414T200000Z
DTEND:20210414T210000Z
SUMMARY:Feindel Virtual Brain and Mind Lecture Series: The locus coeruleus-
 noradrenaline system in Parkinson's disease
URL:/neuro/channels/event/feindel-virtual-brain-and-mi
 nd-lecture-series-locus-coeruleus-noradrenaline-system-parkinsons-330102
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