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UID:20251108T084414EST-3933tOitep@132.216.98.100
DTSTAMP:20251108T134414Z
DESCRIPTION:Acute myeloid leukemia (AML) is an aggressive cancer of the mye
 loid lineage of the blood system. Prior work has shown that a rare subset 
 of leukemic stem cells (LSCs) is able to propagate the disease. LSCs are p
 resently only defined functionally as able to engraft by xenotransplantati
 on in immunocompromised mice. No universal markers for LSCs are currently 
 known\, therefore previous efforts to study LSCs have relied on enriching 
 for them by cell sorting with non-specific markers. In order to better und
 erstand the characteristics essential to LSC self-renewal\, we propose to 
 apply single-cell RNA sequencing (scRNA-seq) to study the transcriptional 
 states within human AML samples. While bulk RNA sequencing yields only an 
 average gene expression profile across many cells\, scRNA-seq recovers tra
 nscripts from thousands of individual cells. This resolution\, coupled wit
 h the lack of required pre-sorting of cells\, provides a less biased view 
 of heterogeneity in cell types and cell states. The overall goal of our re
 search is to exploit scRNA-seq of AML patient samples to study rare leukem
 ic cell populations\, such as LSCs and infiltrating immune cells\, in orde
 r to identify novel\, potentially targetable markers.\n
DTSTART:20200228T160000Z
DTEND:20200228T170000Z
LOCATION:Room 1034\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1
 Y6\, 3655 promenade Sir William Osler
SUMMARY:Seminar: Single-cell transcriptomic analysis of acute myeloid leuke
 mia and immune checkpoint blockade 
URL:/physiology/channels/event/seminar-single-cell-tra
 nscriptomic-analysis-acute-myeloid-leukemia-and-immune-checkpoint-blockade
 -301512
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