BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//132.216.98.100//NONSGML kigkonsult.se iCalcreator 2.20.4//
BEGIN:VEVENT
UID:20251105T184655EST-17802vpDzA@132.216.98.100
DTSTAMP:20251105T234655Z
DESCRIPTION:\n	Fibromyalgia is one of the most prevalent chronic pain condit
 ions\, negatively affecting the lives of 4-6% of the adult population worl
 dwide. Fibromyalgia is a syndrome characterised by diffused pain\, fatigue
  and cognitive symptoms. Despite years of research there are still conside
 rable gaps in our understanding of this syndrome and in our ability to tre
 at it effectively. In recent years there is growing appreciation of the cr
 itical role the gut microbiome plays in health and disease. This rich ecos
 ystem of micro-organisms\, living in and on our body is not only modeled b
 y a variety of medical conditions\, but also plays a role in pathologies p
 ertaining to a wide range of medical fields. Of particular interest is the
  bi-directional interaction of the gut microbiome with the central nervous
  system. This so called gut-brain axis allows the gut microbiome to play a
  role in psychiatric and neurologic conditions. Could the gut microbiome p
 lay a role in chronic pain as well?\n\nTo test this hypothesis we explore 
 the composition and function of the gut microbiome in a cohort of 77 women
  with fibromyalgia and 79 healthy controls. While the overall composition 
 of the gut microbiome of patients was similar to that of controls\, signif
 icant alterations were observed in the relative abundance of several speci
 fic bacterial species. The relative abundance of these species quantitativ
 ely correlated with disease-related variables such as pain\, fatigue and c
 ognitive dysfunction more than with any other variable\, including demogra
 phic\, anthropometric\, comorbidities\, medications and nutritional measur
 es. Serum metabolomic analysis revealed significant alterations in the con
 centration of gut-microbiome derived metabolites including short-chain fat
 ty acids (SCFA) and bile acids. These differentially abundant serum metabo
 lites are known to be metabolized by the differentially abundant bacterial
  species identified in fibromyalgia patients\, indicating altered gut-micr
 obiome function in addition to the observed alteration in its composition.
 \n\nTo explore the possible causal role of the gut microbiome in the patho
 genesis of fibromyalgia\, we used fecal microbiome transplantation (FMT) t
 o germ-free mice. FMT from 3 FM patients and 3 healthy controls were given
  to 32 germ-free mice. Mice receiving FMT from fibromyalgia patients showe
 d significantly decreased thermal and mechanical thresholds and increased 
 mouse-grimace scores when compared to mice receiving FMT from controls\, s
 uggesting higher susceptibility to both evoked and spontaneous pain. Minor
  alterations in sleep\, cognitive and affective measures were also observe
 d.\n\nTaken together\, these results provide first evidence for alteration
 s in both the composition and function of the gut microbiome in humans wit
 h fibromyalgia\, and for a possible causal role of the gut microbiome in p
 ain sensitization in germ-free mice. Exploration of the mechanisms allowin
 g the gut microbiome to modulate pain in fibromyalgia as well as in other 
 pain conditions may pave the way for better understanding of chronic pain 
 and for new diagnostic and therapeutic modalities.\n\nThis seminar will be
  given online via Zoom.\n
DTSTART:20200522T150000Z
DTEND:20200522T160000Z
LOCATION:via Zoom\, McIntyre Medical Building\, CA\, QC\, Montreal\, H3G 1Y
 6\, 3655 promenade Sir William Osler
SUMMARY:Online Seminar: Gut feeling – gut microbiome role in fibromyalgia
URL:/physiology/channels/event/online-seminar-gut-feel
 ing-gut-microbiome-role-fibromyalgia-322053
END:VEVENT
END:VCALENDAR