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UID:20251028T165153EDT-6381Ac1CfN@132.216.98.100
DTSTAMP:20251028T205153Z
DESCRIPTION:When Random Beats Routine: Stochastic Hormone-Sensitive Cancer 
 Deprivation Therapy\n\nRobert H. Austin\, Princeton University\n	Tuesday No
 vember 4\, 12-1pm\n	Zoom Link: https://mcgill.zoom.us/j/87078928687\n	In Per
 son: 550 Sherbrooke\, Room 189\n	\n	Abstract: Deprivation therapies for horm
 one-sensitive cancers\, such as prostate\, breast\, and ovarian malignanci
 es\, embody an evolutionary game in which therapy suppresses drug-sensitiv
 e cells but leaves resistant subclones unchecked. The ultimate threat to t
 he patient is not the size of the tumor per se but the metabolic load impo
 sed by the tumor ecosystem on the body. In contrast to intuition\, we show
  that pseudo-randomized therapy schedules\, a feed-º£½Ç¾«Æ·ºÚÁÏ strategy withou
 t cell number monitoring\, can paradoxically prolong survival by sustainin
 g sensitive cell populations and minimizing metabolic load\, an example of
  Parrondo’s paradox. By contrast\, systematic therapy schedules drive sens
 itive cells to extinction and accelerate resistant takeover. We propose th
 at therapy optimization should be cast as a Pareto problem: maximizing tim
 e to metabolic overload while minimizing drug burden. This metabolic persp
 ective reframes adaptive therapy as an eco-evolutionary control problem\, 
 highlighting how noise\, randomness\, and evolutionary games intersect in 
 cancer treatment.\n
DTSTART:20251104T170000Z
DTEND:20251104T180000Z
SUMMARY:QLS Seminar - Robert H. Austin 
URL:/qls/channels/event/qls-seminar-robert-h-austin-36
 8583
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