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Synthetic intrinsically disordered proteins (SynIDPs) are genetically encoded polymers of short peptide repeats that exhibit upper critical solution temperature (UCST) or lower critical solution temperature (LCST) phase behavior, like many naturally occurring IDPs. SynIDPs solely recapitulate the intrinsically disordered regions of native IDPs that are believed to drive the phase separation behavior of native IDPs. Because of their simplicity, the鈥痯hase behavior of SynIDPs can be rationally tuned at the molecular level by control of their sequence, composition, and chain length. I will describe how SynIDPs can be used to develop simple but powerful tools for biotechnology and medicine and for the design of synthetic biomolecular condensates in live cells to control diverse cellular functions.听

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Bio:

Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering at Duke University. His areas of research include genetically encoded biomaterials, the development of synthetic biomolecular condensates for synthetic biology, and point-of-care clinical diagnostics.听 He has published ~370 papers, has been cited 52,000 times, has a Google Scholar H-index of 120, and has 171 patents and patent applications. Prof. Chilkoti was awarded the Clemson Award for Contributions to the Literature by the Society for Biomaterials in 2011, the Robert A. Pritzker Distinguished Lecture award by the Biomedical Engineering Society in 2013, was elected to the National Academy of Inventors in 2014, received the Distinguished Alumni award from the Indian Institute of Technology, Delhi in 2015, and the Diamond award from the College of Engineering at the University of Washington in 2017, and the Technology Innovation and Development Award from the Society for Biomaterials in 2025. He is a fellow of the American Association for the Advancement of Science. He is the founder of six start-up companies, one of of which went public, and two were acquired.听